NEXT MEETING: ST. LOUIS, MISSOURI - AUGUST 4-8 2025

Laboratories worldwide have implemented analytical workflows and initiatives to enhance sustainability and safety, including the substitution of hazardous chemicals and adoption of advanced analytical technologies. However, the application of these greener approaches in regulatory testing within the United States has been constrained due to the limited flexibility permitted in many EPA-approved methods supporting environmental regulation. Since 2023, we evaluated and optimized the entire workflow (sample collection, preparation, and analysis) for the analysis of Semivolatile Organic Compounds (SVOCs) included in EPA by GC Triple Quadrupole (GC-MS/MS). By re-evaluating the entire analytical workflow, we achieved a 100-fold reduction in dichloromethane (DCM) usage while maintaining analytical performance, adherence to the DCM Rule (enacted by EPA in 2024) and alignment with global laboratory sustainability initiatives. In this presentation, we will demonstrate how this GC-MS/MS based workflow enhances both environmental and operational sustainability without compromising quality assurance standards. We will also discuss the GC-MS/MS method performance, particularly for critical and problematic compounds.