Reducing and Replacing DCM in Semi-Volatile Organic Compound Extraction through Optimized SPE Workflow

Automation & Innovation for Sample Preparation
Oral Presentation

Prepared by J. Nichol, R. Chen, H. Li
PromoChrom Technologies, 13351 Commerce Parkway, Richmond, British Columbia, V7E 1Z7, Canada


Contact Information: [email protected]; 18337724766 ext 702

ABSTRACT

With the EPA’s new regulations requiring reduced occupational exposure to methylene chloride (DCM) by May 5 2025, the trace organic analytical community is seeking alternative extraction techniques to replace traditional DCM-heavy liquid-liquid extraction (LLE) methods. Solid-phase extraction (SPE) has emerged as a viable solution, offering both significant DCM reduction and the potential for solvent alternatives.

This presentation explores an optimized SPE workflow designed to extract over 100 semi-volatile organic compounds (SVOCs) from EPA Method 525 and TCLP semi-volatiles lists. By leveraging advancements in SPE technology, this method achieves high extraction efficiency while significantly reducing solvent consumption. The shift towards alternative solvents are also made possible through improvements along the sample preparation process. Experimental results will be presented, comparing DCM-based and non-DCM approaches in terms of recoveries, precision, and efficiency.

To further minimize human exposure to hazardous solvents, these workflow advancements have been integrated into automated systems, providing an effective solution for laboratories adapting to the new regulatory requirements.